Do not take if you are pregnant or breastfeeding. Consult a health care practitioner if symptoms persist or worsen. Consult a health care practitioner prior to use if you are taking blood pressure medication, cardiac glycosides such as digitalis/digoxin, if you have diabetes, if you have stomach ulcers or inflammation, or if you are following a low protein diet. If you are taking any other medications or natural health products, consult a health care practitioner prior to use, as piperine may alter their effectiveness. Do not use if seal is broken. Keep out of reach of children. Keep sealed, store in a cool, dry place at 15–25ºC.